Efficacy of Nimodipine Administration on Vasospasm after Subarachnoid Hemorrhage

I reviewed three articles on the efficacy of Nimodipine administration on vasospasm after subarachnoid hemorrhage in order to produce improved clinical outcomes.

Efficacy of Nimodipine Administration on Vasospasm after Subarachnoid Hemorrhage

Although the outcomes for these patients continues to remain poor, the current evidence suggests that calcium antagonist like Nimodipine can play an integral part of providing the best possible care for this populuation subset. The authors demonstrate that continuous local intra-arterial nimodipine administration (CLINA) is both safe and effective in helping reverse vasospasm and prevent delayed ischemic neurological deficit commonly associated with subarachnoid hemorrhage. They show that intra-arterial nimodipine administration shows good vessel widening effects against vasospasm. Additionally, the authors observed a positive correlation between the degree of blood vessel expansion and the improvement in clinical symptoms.

Here are the three main articles referenced in the paper. Unfortunately, only the first article is available without a fee.

  1. Angiographic Features and Clinical Outcomes of Intra-Arterial Nimodipine Injection in Patients with Subarachnoid Hemorrhage-Induced Vasospasm
  2. Continuous intra-arterial infusion of nimodipine at the onset of resistant vasospasm in aneurysmal subarachnoidal hemorrhage – A technical resport ($)
  3. Continuous Local Intra-arterial Nimodipine Administration in Severe Symptomatic Vasospasm after Subarachnoid Hemorrhage ($)

Here are the supporting related references, and fortunately most of them are available without a fee.

  1. American Association of Neurological Surgeons – Cerebral Aneurysm
  2. American Association of Neuroscience Nurses – Care of the Patient with Aneurysmal Subarachnoid Hemorrhage
  3. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association
  4. The Chocrane Library – Calcium Antagonists in Aneurysmal Subarachnoid Hemorrhage ($)
  5. Intra-Arterial Nimodipine for Severe Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage: Influence on Clinical Course and Cerebral Perfusion
  6. The role of transcranial Doppler ultrasonography in the diagnosis and management of vasospasm after aneurysmal subarachnoid hemorrhage ($)
  7. Inflammation and cerebral vasospasm after subarachnoid hemorrhage ($)
  8. Angiographic Features and Clinical Outcomes of Intra-Arterial Nimodipine Injection in Patients with Subarachnoid Hemorrhage-Induced Vasospasm
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