Core Papers

Historic and landmark – a broad sample

(Based on the ICU top-twenty by Dr J Chantler & the Intensive Care Medicine Worth Knowing site – with thanks)

Try these ten(ish) first:

  1. EGDT– Rivers E et al.
    ‘Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock’.
    New England Journal of Medicine 345, no. 19 (2001): 1368–1377.
  1. Cook DJ et al..
    ‘Stress Ulcer Prophylaxis in Critically III Patients’.
    JAMA: The Journal of the American Medical Association 275, no. 4 (1996): 308–314.
  1. Cook DJ & Crowther MA.
    ‘Thromboprophylaxis in the Intensive Care Unit: Focus on Medical-Surgical Patients’.
    Critical Care Medicine 38, no. 2 Suppl (February 2010): S76–82. doi:10.1097/CCM.0b013e3181c9e344.
  1. ARDSNET ‘Lower Vt’– De Campos, T et al.
    Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. The Acute Respiratory Distress Syndrome Network’.
    N Engl J Med342, no. 18 (2000): 1302–130g.
  1. SSC– Dellinger R et al.
    ‘Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock’.
    Critical Care Medicine 41, no. 2 (February 2013): 580–637. doi:10.1097/CCM.0b013e31827e83a
  1. ABC– Girard TD et al.
    ‘Efficacy and Safety of a Paired Sedation and Ventilator Weaning Protocol for Mechanically Ventilated Patients in Intensive Care (Awakening and Breathing Controlled Trial): A Randomised Controlled Trial’.
    Lancet 371, no. 9607 (12 January 2008): 126–134. doi:10.1016/S0140-6736(08)60105-1.
  1. NICE-SUGAR – Finfer S et al.
    ‘Intensive versus Conventional Glucose Control in Critically Ill Patients’.
    N Engl J Med 360, no. 13 (2009): 1283–1297.
  1. Berenholtz SM et al.
    ‘Eliminating Catheter-Related Bloodstream Infections in the Intensive Care Unit*’.
    Critical Care Medicine 32, no. 10 (2004): 2014–2020.
  1. Cade, J F.
    ‘High Risk of the Critically Ill for Venous Thromboembolism’.
    Critical Care Medicine 10, no. 7 (July 1982): 448–450.
  1. CORTICUS – Sprung C et al.
    ‘Hydrocortisone Therapy for Patients with Septic Shock’.
    The New England Journal of Medicine 358, no. 2 (10 January 2008): 111–124. doi:10.1056/NEJMoa071366.
  1. Knaus WA et al.
    ‘APACHE II: A Severity of Disease Classification System’.
    Critical Care Medicine 13, no. 10 (October 1985): 818–829.
  1. Nolan JP et al.
    ‘Therapeutic Hypothermia after Cardiac Arrest: An Advisory Statement by the Advanced Life Support Task Force of the International Liaison Committee on Resuscitation’.
    Circulation 108, no. 1 (2003): 118.
  1. ARDSNET steroids– Steinberg KP et al.
    ‘Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome’.
    The New England Journal of Medicine 354, no. 16 (20 April 2006): 1671–1684. doi:10.1056/NEJMoa051693.
  1. TracMan – Young D et al.
    ‘Effect of Early vs Late Tracheostomy Placement on Survival in Patients Receiving Mechanical Ventilation: The TracMan Randomized Trial’.
    JAMA: The Journal of the American Medical Association 309, no. 20 (22 May 2013): 2121–2129. doi:10.1001/jama.2013.5154
  1. TRICC – Hébert, PC et al
    ‘A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care’.
    New England Journal of Medicine 340, no. 6 (1999): 409–417.

Now try these:

  1. Bickell WH et al.
    ‘Immediate versus Delayed Fluid Resuscitation for Hypotensive Patients with Penetrating Torso Injuries’.
    The New England Journal of Medicine 331, no. 17 (27 October 1994): 1105–1109. doi:10.1056/NEJM199410273311701.
  1. PROSEVA– Guérin C et al.
    ‘Prone Positioning in Severe Acute Respiratory Distress Syndrome’.
    The New England Journal of Medicine 368, no. 23 (6 June 2013): 2159–2168. doi:10.1056/NEJMoa1214103.
  1. CHEST– Gattas DJ et al.
    ‘Fluid Resuscitation with 6 % Hydroxyethyl Starch (130/0.4 and 130/0.42) in Acutely Ill Patients: Systematic Review of Effects on Mortality and Treatment with Renal Replacement Therapy’.
    Intensive Care Medicine 39, no. 4 (14 February 2013): 558–568. doi:10.1007/s00134-013-2840-0.
  1. Dowdy DW et al.
    ‘Quality of Life in Adult Survivors of Critical Illness: A Systematic Review of the Literature’.
    Intensive Care Medicine 31, no. 5 (1 April 2005): 611–620. doi:10.1007/s00134-005-2592-6.
  1. Esteban A et al
    ‘Noninvasive Positive-Pressure Ventilation for Respiratory Failure after Extubation’.
    New England Journal of Medicine 350, no. 24 (2004): 2452–2460.
  1. Goldfrad, C, and K Rowan.
    ‘Consequences of Discharges from Intensive Care at Night’.
    Lancet 355, no. 9210 (1 April 2000): 1138–1142. doi:10.1016/S0140-6736(00)02062-6.
  1. Gray A et al.
    ‘Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema’.
    New England Journal of Medicine 359, no. 2 (2008): 142–151.
  1. MIDEX & PRODEX– Jakob SM et al.
    ‘Dexmedetomidine vs Midazolam or Propofol for Sedation during Prolonged Mechanical Ventilation: Two Randomized Controlled Trials’.
    JAMA: The Journal of the American Medical Association 307, no. 11 (21 March 2012): 1151–1160. doi:10.1001/jama.2012.304
  1. Kress JP et al.
    ‘Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation’.
    The New England Journal of Medicine 342, no. 20 (18 May 2000): 1471–1477. doi:10.1056/NEJM200005183422002.
  1. Lightowler JV et al
    ‘Non-Invasive Positive Pressure Ventilation to Treat Respiratory Failure Resulting from Exacerbations of Chronic Obstructive Pulmonary Disease: Cochrane Systematic Review and Meta-Analysis’.
    BMJ 326, no. 7382 (25 January 2003): 185–185. doi:10.1136/bmj.326.7382.185.
  1. ACCEPT– Martin CM et al.
    ‘Multicentre, Cluster-Randomized Clinical Trial of Algorithms for Critical-Care Enteral and Parenteral Therapy (ACCEPT)’.
    CMAJ: Canadian Medical Association Journal = Journal de l’Association Medicale Canadienne 170, no. 2 (20 January 2004): 197–204.
  1. McQuillan P et al.
    ‘Confidential Inquiry into Quality of Care before Admission to Intensive Care’.
    BMJ (Clinical Research Ed.) 316, no. 7148 (20 June 1998): 1853–1858.
  1. ARDSNET PAC – Wheeler AP et al.
    Pulmonary-Artery versus Central Venous Catheter to Guide Treatment of Acute Lung Injury’.
    The New England Journal of Medicine 354, no. 21 (25 May 2006): 2213–2224. doi:10.1056/NEJMoa061895.
  1. Palevsky PM et al.
    Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury’.
    N Engl J Med 359, no. 1 (2008): 7–20.
  1. MENDS– Pandharipande PP et al.
    Effect of Sedation with Dexmedetomidine vs Lorazepam on Acute Brain Dysfunction in Mechanically Ventilated Patients: The MENDS Randomized Controlled Trial’.
    JAMA: The Journal of the American Medical Association 298, no. 22 (12 December 2007): 2644–2653. doi:10.1001/jama.298.22.2644.
  1. CESAR– Peek G et al.
    ‘Conventional Ventilatory Support vs Extracorporeal Membrane Oxygenation for Severe Adult Respiratory Failure’.
    BMC Health Services Research 6, no. 1 (2006): 163.
  1. Simpson F & Doig GS.
    ‘Parenteral vs. Enteral Nutrition in the Critically Ill Patient: A Meta-Analysis of Trials Using the Intention to Treat Principle’.
    Intensive Care Medicine 31, no. 1 (January 2005): 12–23. doi:10.1007/s00134-004-2511-2.
  1. Sud, SM et al.
    ‘Effect of Mechanical Ventilation in the Prone Position on Clinical Outcomes in Patients with Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-Analysis’.
    Canadian Medical Association Journal 178, no. 9 (22 April 2008): 1153–1161. doi:10.1503/cmaj.071802.



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